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Abstract
Context: Intestinal ischemia-reperfusion (IIR) not only leads to severe intestine damage but also induced subsequent destruction of remote organs.
Objective: We investigated the protective effect of Pistascia lentiscus L. (Anacardiaceae) oil on IIR.
Materials and methods: Wistar rats were divided into three groups: sham, intestinal IR and P. lentiscus pretreatment (n = 18 each). In the pretreatment group, oil was administered 1 h before induction of warm ischemia.
Results: IIR led to severe liver damage manifested as a significant (p < .05) increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Pistacia lentiscus oil decreased the visible intestinal damage, as well as a significant decrease in serum AST and ALT levels. In addition, Pistacia lentiscus reduce liver injury, as evidenced by the decrease in liver tissue myeloperoxidase activity and lipoperoxidation (MDA) level.
Conclusion: Pistascia lentiscus attenuates liver injury induced by IIR, attributable to the antioxidant and anti-inflammatory effect.
Acknowledgements
The authors would like to express their sincere gratitude to Dr. Adel Khathraoui from the English Department at the Faculty of Science and Arts-Khulais, University of Jeddah for his valuable proofreading and language polishing services.
Disclosure statement
The authors declared no conflicts of interest.
Funding
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.