Effects of exercise training on kinin receptors expression in rats with myocardial infarction

Abstract

Objectives: The objective of this study is to determine the role of kinin B1 and B2 receptors in exercise-induced cardiac muscle angiogenesis.

Method: Thirty Wistar rats were randomly assigned to the control group, the myocardial infarction group and the exercise training group (myocardial infarction model was made and received 30 min exercise training on a treadmill). After 4 weeks of experiment, cardiac muscle was harvested.

Results: B1 and B2 receptor mRNA and protein levels in the exercise-training group were significantly higher than those in the myocardial infarction group, which were higher than those in the control group. Capillary number in the cardiac muscle also showed the same tendency. There was a correlation between capillary number and B1 receptor protein (not B2 receptor protein) in the all groups.

Conclusion: Kinin B1 and B2 receptors play roles in exercise-induced cardiac muscle angiogenesis. However, the B1 receptor appears to have a more prominent role.

Keywords:

• Angiogenesis
• kinin B1 receptor
• kinin B2 receptor
• exercise training
• myocardial infarction

Acknowledgements

This study was approved by the Ethics Committee of Affiliated Zhongshan Hospital of Dalian University.

Statement of animal rights

The study protocol complied with the Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health (NIH Publication no. 85–23, revised 1996).

Disclosure statement

The authors have declared that no competing interests exist.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant No. 81071598].