Abstract
Context: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values.
Objective: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system.
Materials and methods: Rats were exposed either to THC, THC + PS (100 mg/kg), or THC + PS (200 mg/kg).
Results: Our study showed that THC induced severe disorders in the functional sperm parameters. A decrease in antioxidant activities and their genes expression were observed in the same group, compared to the controls. Our molecular data showing also a severe DNA breakdown in the testis of THC treated group. Moreover, THC treated group showed severe histopathological changes.
Conclusions: Our results revealed that PS extracted from Ulva lactuca alleviated the THC induced reprotoxicity and reduced oxidative stress damages, DNA breakdown and histological injuries in the testis.
Acknowledgements
The present work was supported by the Ministry of Higher Education and Scientific Research, Tunisia, and the DGRST grants (Direction Générale de la Recherche Scientifique et Technique-Tunisie. Appui à la Recherche Universitaire de base LR/01/ES-23).
Disclosure statement
No potential conflict of interest was reported by the authors.