Abstract
Context: Crimean–Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease.
Objective: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I–II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF.
Methods: Seventy CCHF patients and 39 healthy control volunteers were included in the study.
Results: Serum MDA and TAS levels were significantly higher (p < .0001) and serum TOS and OSI levels were significantly lower (p < .0001) in both the acute period and at 6th-month follow-up in the CCHF patients compared to the healthy volunteers. CA II levels were significantly higher in the acute period compared to the healthy volunteers (p < .005) and were significantly lower at 6th-month follow-up (p < .05).
Conclusion: Serum MDA and CA II autoantibodies appear to reflect oxidative stress status and disease progression in CCHF and may be used as biomarkers for oxidative stress and disease progression.
Disclosure statement
None of the authors had any financial or personal relationships with other individuals or organizations that might inappropriately influence their work during the submission process.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.