Abstract
Objective: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity.
Methods: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD).
Results: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity by 34%, decreased body weight by 20% and modulated lipid profile, showed a decrease in total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma by 59% and 42%, respectively, and increased the HDL-cholesterol (HDL-C) level by 31%. In addition, the administration of phytoestrogens to HFFD-mice exerts an inhibitory effect on α-amylase activity and decreased glucose level by 28% and increase in liver glycogen level by 33%; and ameliorate oral glucose tolerance test.
Conclusions: This study demonstrate that phyto(E2) has both a promising potential with regards to the inhibition of intestinal lipase and α-amylase activities, and a valuable hypoglycemic and hypolipidemic function.
Acknowledgements
The authors wish to express their sincere gratitude to Pr. Anouar Smaoui from the English department at the Faculty of Science of Sfax for carefully proofreading and polishing the language of the presented paper.
Disclosure statement
No potential conflict of interest was reported by the authors.