Development of catechin–phospholipid complex to enhance the bioavailability and modulatory potential against cadmium-induced oxidative stress in rats liver

Abstract

The natural flavonoid (catechin) has been shown to possess a multitude of pharmacological activities. However, oral administrated catechin (CT) failed to fulfil its therapeutic potential due to poor absorption and low bioavailability. Thus, is a pressing need to develop a new approach from to increase its intestinal absorption and improved bioavailability. In this work, we intended the increase the bioavailability of CT by preparing catechin-phospholipid complex (CT–PH) and evaluate the protective effect of CT–PH complex against cadmium caused liver injuries in rats. Oral bioavailability of CT and CT–PH complex was evaluated in rats and the plasma CT was estimated by HPLC analysis. The greater absorption of CT–PH complex rats indicated that improved bioavailability. Liver function markers, lipid peroxidation, protein oxidation, antioxidant status and histopathological changes were determined in normal and treated rats. Moreover, biochemical analysis and histopathological examinations indicated that CT–PH provided better protection to rat liver than free CT.

Keywords:

• Catechin
• Catechin–phospholipid complex
• bioavailability
• hepatoprotective potential

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors acknowledge the Ministry of Higher Education, Scientific Research and Technology, Tunisia, for supporting this study.