Hypoglycaemic and hypolipidemic activities of Alhagi camelorum in streptozotocin-induced diabetes in Wistar rats

Abstract

This study investigates the alcoholic extract effect of Alhagi camelorum on blood glucose and lipid profiles in diabetic rats made by streptozotocin (STZ). Male rats were divided into four groups. The control group received a normal diet. The diabetic group was induced by STZ and two diabetic experimental groups received alcoholic extracts of A. camelorum at a dose of 200 and 300 mg/kg by means of gavage, respectively. Blood samples were collected on 21st from all the groups. Findings show that there is a significant increase in the level of fasting blood sugar and lipid profiles in diabetic group when the results compared to the control group (p < .05). The same factors showed a drop in groups receiving extract. The levels of insulin and high-density lipoprotein (HDL) were increased in groups that received alcoholic extract. Results indicate that alcoholic extract of A. camelorum decreases the rate of hyperglycaemia and hyperlipidaemia associated with diabetes.

Keywords:

• Alhagi camelorum
• diabetes
• glucose
• lipid
• streptozotocin

Acknowledgements

The authors appreciated the Deputy of Research and Training of Islamic Azad University of Damghan, Damghan, Iran. The results of this study were part of PhD student thesis.

Disclosure statement

The authors have declared that there is no conflict of interest.