Biochemical studies of adiponectin gene polymorphism in patients with obesity in Egyptians

Abstract

Background

Adiponectin gene polymorphisms have recently been reported to be associated with obesity. In Egypt, obesity has expanded especially with the changing nourishment propensities and the inexorably inactive ways of life, with almost 70 percent of the Egyptian populations being obese.

Aim

To assess the relationship of the adiponectin gene (ADIPOQ) polymorphism in patients with Obesity in Egyptians.

Subjects and methods

This study included 100 patients with obesity and 97 random controls.

Results

Adiponectin rs1501299 polymorphism showed significant difference cases with different obesity grades where the T/T genotype was relatively higher in higher classes of obesity (Class II and III; (66.7% and 55.6% respectively, p = 000), which determines the susceptibility to obesity.

Conclusion

Adiponectin rs1501299 polymorphism might be a candidate gene, which determines the susceptibility to obesity. Larger studies are necessary to confirm these findings in various populations.

Keywords:

• Obesity
• Egypt
• adiponectin
• polymorphism

Acknowledgements

We wish to express our sincere appreciation to all of the staff members for their help in performing field work Thanks to all of the study participants.

Disclosure statement

No potential conflict of interest was reported by the authors.