Prediction of gestational diabetes mellitus in the first trimester by fasting plasma glucose which cutoff is better?

Abstract

Objective

We aimed to predict subsequent gestational diabetes mellitus (GDM) by fasting plasma glucose (FPG) in the first trimester.

Methods

Healthy pregnant women who were screened for GDM at 24–28 gestational weeks and had FPG levels calculated during their first antenatal visit and less than 14 gestational weeks were included in this study.

Results

Of the 2605 women who were recruited for the study, 245 (9.4%) were diagnosed with GDM at weeks 24–28. The diagnostic accuracy for FPG predicting GDM was 66.5, 78.4, and 88.2 for the cutoff values of 87.5 mg/dl, 92 mg/dl, and 99.5 mg/dl, respectively.

Conclusions

FPG values which are within the normoglycaemic range constitute an independent risk factor for the development of GDM. The threshold for gestational diabetes diagnosis must be revised.

Keywords:

• Gestational diabetes
• screening
• cutoff
• first trimester

Disclosure statement

The authors report no conflicts of interest.