Swimming training modulates lung injury induced by ovariectomy in diabetic rats: involvement of inflammatory and fibrotic biomarkers

Abstract

Context

Previous studies have noted that the incidence of inflammatory and fibrotic diseases is higher in diabetic menopausal women.

Objective

In the present study, we evaluated effects of swimming training on inflammatory and fibrotic biomarkers in the lung of ovariectomized diabetic rats.

Materials and methods

Forty female rats were assigned into four groups: sham; rats underwent surgery without ovariectomies, OVX: rats that underwent ovariectomies, OVX.Dia: ovariectomized rats with high-fat diet, OVX.Dia. Exe: ovariectomized diabetic rats with 8 weeks of swimming training. At the end of experiment, protein expressions were assessed with western blot. Lung sections were subjected to immunohistochemical and haematoxylin eosin staining.

Results

There was a significant difference in the protein expressions between exercise and ovariectomized diabetic groups (p < .05).

Conclusion

The present study showed strong potential of swimming training on oestrogen deficient diabetic lung. These data encourage further investigation into the inclusive effects of exercise in menopausal diabetic women.

Keywords:

• Ovariectomy
• diabetes
• inflammation
• fibrosis
• exercise

Acknowledgements

The present paper is extracted from the PhD thesis of Faeze Daghigh. “Combination effect of swimming and genistein on the ERK signaling leading to apoptosis and histologic changes in the lung tissue of diabetic ovariectomized rats” The authors would like to thank drug applied.

Disclosure statement

No potential conflict of interest was reported by the authors.