Genetic polymorphisms of ACE I/D, IL-1β G > A and IL-4 VNTR among Egyptian subjects with rheumatoid arthritis

Abstract

Background

Various reports examined the contribution of ACE I/D, IL-1β G > A and IL-4 VNTR with the susceptibility to RA but with conflicting findings. The goal of this study is to assess the impact of these three variants with the susceptibility, clinical and biochemical markers in addition to different composite indices of RA.

Subjects and Methods

This case-control survey enclosed 120 RA Egyptian patients who were emulated with 150 healthy controls from the same territory. Their genomic DNA was genotyped utilising the PCR approach.

Results

RA patients with ACE allele (D) and IL-4 VNTR allele (2 R) were expressively higher emulated with healthy controls (p < .05). Nevertheless, RA patients with IL-1β (A allele) failed to achieve an apparent significant emulated with healthy controls (p > .05).

Conclusions

This work specifies a noteworthy association for ACE I/D and IL-4 VNTR but not IL-1β G > A polymorphisms with RA susceptibility among Egyptian subjects.

Keywords:

• Angiotensin-converting enzyme (ACE)
• IL-1β (Interleukin-1 beta)
• IL-4 (Interleukin-4)
• disease activity score 28 (DAS28)
• rheumatoid arthritis (RA)

Acknowledgement

Authors are appreciative for the staff affiliates of Rheumatology Department, Mansoura University Hospitals, Egypt, for their assistance in choosing cases under the work.

Disclosure statement

No potential conflict of interest was reported by the authors.