https://orcid.org/0000-0001-7644-2508
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Abstract
Context
Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.
Objective
This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (MDA), calcium and magnesium in fructose-induced diabetic rats.
Materials and methods
Thirty rats were grouped into non-diabetic controls, diabetic controls, diabetic rats given vitamin E + C, calcium + magnesium and vitamin E + C + calcium + magnesium. The analytes were evaluated using standard methods. Statistical significance was set at p < .05.
Results
The diabetic controls had significantly higher MDA (p = .036) but lower (p = .0001) TAC, calcium, magnesium, sperm count, and %motility than the non-diabetic controls. The Vitamin C + E group showed the greatest improvement as they had the highest values of seminal parameters compared to other supplemented groups.
Conclusion
Combined Vitamin C + E supplementation may provide better ameliorative benefits than a combination of Vitamin C, E, calcium and magnesium in diabetics.
Acknowledgements
The authors thank Mr E. Umoh of the Department of Physiology, University of Calabar, for his technical assistance.
Authors’ contribution
Bassey I. E. and Ikpi D. E. initiated and designed the research, Bassey I. E. did the analysis and interpretation of data. Onyeukwu C. C., Nwankwo N. P., and Udofia I performed the experiment and wrote the initial draft manuscript while Isong I. K. P. and Akpan U. O., critically reviewed the manuscript.
Disclosure statement
The authors report no declarations of interest.