Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus

Abstract

Objective

We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM).

Material and Methods

The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, and Group III: GDM patients.

Results

Fasting plasma glucose and Homeostatic Model Assessment for Insulin Resistance index were significantly higher in GDM cases (Group 3). Regarding the MIOX levels, significantly higher levels were recorded at 0-h in Group 3 compared to Groups 1 and 2. Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029).

Conclusions

MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism.

Keywords:

• Serum Myo-inositol oxygenase
• gestational diabetes mellitus
• second trimester

Disclosure statement

No potential conflict of interest was reported by the author(s).