Abstract
Objectives
This study investigated the effect of dexmedetomidine on the oxidant–antioxidant (thiol/disulphide) balance.
Methods
A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Groups D (Dexmedetomidine) and IR + D were administered 100 μg/kg dexmedetomidine. Oxidant–antioxidant (thiol/disulphide) levels were measured. Kidney tissue was examined histopathologically.
Results
No statistically difference was found between the groups in terms of thiol–disulphide averages, while IMA, TOS and thiol–disulphide results showed a minimal decrease in Group IR + D compared to Group IR (p > 0.05). Tubular lesions and necrosis were found in 26–50% of tubules in Group IR. Tubular damage and necrosis in Group IR + D declined to 5–25% .
Conclusions
No statistically difference was found in the study where OSI index, thiol/disulphide balance and IMA were measured together as biochemical values.
Disclosure statement
No potential conflict of interest was reported by the author(s).