Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure

Abstract

We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups (p < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups (p < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients (p < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure.

Keywords:

• Heart failure
• left ventricular ejection fraction
• mortality
• thiol/disulphide homeostasis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study received funding from Ahi Evran University Scientific Research Committee (Grant number: TIP.A4.19.013).