Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants

Abstract

Background

The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants.

Methods

Our study included male obese, without co-morbidities (n = 29), and healthy participants (n = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.

Results

miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants.

Conclusion

We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.

Keywords:

• miR-21
• miR-146a
• CD36
• adipocytokines
• obesity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

We are not linking to or uploading research data, but data will be made available on request.