Genetic polymorphisms −137 (G > C) (rs187238) and −607 (C > A) (rs1946518) and serum level of interleukin 18 in Fars ethnic groups with metabolic syndrome in Northern Iran

Abstract

Introduction

We aimed to determine the genetic polymorphisms and serum level of interleukin 18 in Fars ethnic groups.

Material and methods

226 Fars ethnic groups were participated. The ATP III criteria were used to assess MS components. The SNPs of the IL-18 gene were determined with ARMS-PCR.

Results

The GG, GC, and CC genotypes of −137 were 50%, 40%, and 10%. The CC, CA, and AA genotypes of −607 were 45%, 37%, and 18%. The GG, GC, and CC genotypes of −137 were 44.20%, 43.40%, and 12.40%, and were 55.75%, 36.28%, and 7.97% in subjects with and without MS, respectively. The CC, CA, and AA genotypes of −607 were 48.70%, 37.20%, and 14.20% and were 41.60%, 37.20%, and 21.20% in both groups, respectively.

Conclusion

IL-18 gene may different in specific populations, different ethnic groups and geographic regions. The IL-18 polymorphisms might not be used as a marker of metabolic syndrome.

Keywords:

• Genetic polymorphism
• interleukin 18
• Fars ethnic
• metabolic syndrome
• Iran

Ethics and consent statement

The Ethical Committee of Research Deputy of Golestan University of Medical Sciences has approved the study (Ethic number: IR.GOUMS.REC.1397.197).

Acknowledgements

The authors thank the Research Deputy of Golestan University of Medical Sciences for financial support. This research project was derived from an MSc thesis in Clinical Biochemistry. The corresponding author wishes to thank Mrs Roja Aghajani for her sincere help.

Disclosure statement

The authors declared no conflicts of interest.

Additional information

Funding

This work has been supported by the Research Deputy of the Golestan University of Medical Science.