Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case–control study

Abstract

Background

The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL).

Methods

A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method.

Results

There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p > .05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p > .05). However, patients group had higher level of sd-LDL compared to controls (p < .05).

Conclusion

FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis.

Keywords:

• Atherosclerosis
• fatty acid-binding protein 2
• C-reactive protein
• small dense-LDL

Acknowledgements

The authors appreciate the assistance provided by all staff of Shahid Madani Hospital and all the people participating in this study.

Disclosure statement

The authors declare that they have no conflicts of interest.

Data availability statement

The data that support the findings of this study are available on request from the corresponding author, Gholamreza Shahsavari. The data is not publicly available due to restrictions e.g. their containing information that could compromise the privacy of research participants.

Additional information

Funding

The work described in this manuscript was part of the MSc thesis of Banafsheh Yalameha in clinical biochemistry. This work was supported by Lorestan University of Medical Sciences.