Securidaca inappendiculata stem extract confers robust antioxidant and antidiabetic effects against high fructose/streptozotocin induced type 2 diabetes in rats. Exploration of bioactive compounds using UHPLC-ESI-QTOF-MS

Abstract

Diabetes mellitus is the most deadly and most prevalent metabolic disease of contemporary times. This study evaluated the antidiabetic, antioxidant, and pancreato-protective effects of Securidaca inappendiculata extract (SIE) in high-fructose/streptozotocin-induced type 2 diabetes. SIE (50, 100, and 200 mg/kg) was administered to diabetic rats for 8 weeks, thereafter glycaemic parameters, pancreatic β cell function, lipid profile, hepatorenal function, and antioxidant parameters were evaluated in diabetic rats treated SIE. The results indicated that treatment with SIE markedly lowered blood glucose, lipid parameters, hepatorenal function parameters, and lipid peroxidation at the end of the intervention. Additionally, serum insulin levels were significantly increased as supported by restoration of pancreatic β-cell cells in the H&E staining. Moreover, SIE also upregulated serum antioxidant enzyme activities in the treated diabetic rats. The results revealed that SIE possesses potent antihyperglycemic and antihyperlipidemic and antioxidant effects with the considerable restoration of pancreatic β-cells function.

Keywords:

• Securidaca inappendiculata
• Antihyperglycemic activity
• Antihyperlipidemic activity
• Antioxidant activity
• Type 2 diabetes mellitus

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data associated to the findings in this study are available upon reasonable request from the corresponding author (O.J.O.). The data are not publicly available due to restrictions relating to the process of patent application.

Additional information

Funding

This work was supported by the funds from the University Income, Prince of Songkla University, Thailand (Project number: TTM6302008S).