Bevacizumab for the treatment of intraretinal cystic spaces in a patient with gyrate atrophy of the choroid and retina

ABSTRACT

Background: Gyrate atrophy of the choroid and retina is a rare autosomal recessive condition characterized by chorioretinal atrophy due to deficiency of the enzyme ornithine aminotransferase that can be complicated by intraretinal cystic spaces.

Case report: A 15-year-old female complaining of gradually progressive diminution of vision in both eyes preceded by night blindness was found to have gyrate atrophy of the choroid and retina with intraretinal cystic spaces that was evaluated using multimodal imaging including fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. Functional and anatomical improvement of the intraretinal cystic spaces was achieved with monthly intravitreal bevacizumab injections.

Conclusion: Repeated intravitreal bevacizumab injections can result in anatomical and functional improvement of intraretinal cystic spaces in patients with gyrate atrophy of the choroid and retina.

KEYWORDS:

• Bevacizumab
• intraretinal cystic spaces
• gyrate atrophy of the choroid and retina
• hyperornithinemia
• optical coherence tomography
• optical coherence tomography angiography

Ethical approval

This report was approved by Cairo University research ethics committee and followed the tenets of the Declaration of Helsinki.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.