Association of VEGF Gene Polymorphisms with Diabetic Retinopathy in a South Indian Cohort

Abstract

Background: Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3′UTR variation are studied for association with DR. Materials and Methods: Type 2 diabetic patients with and without retinopathy were recruited. The −634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests. Results: No significant association was observed between genotypes, alleles and haplotypes of −634C/G and 936C/T polymorphisms and DR or its severity. However, C(−634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3). Conclusion: Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.

Keywords:

• diabetic retinopathy
• VEGF
• genetic polymorphism
• type 2 diabetes
• south India