The Relation of White Matter Hyperintensities to Cognitive Performance in the Normal Old: Education Matters

ABSTRACT

This study examined whether the severity of cerebral white matter abnormalities (evident on MR images as white matter hyperintensities (WMH)) was related to the cognitive performance of 141 high-functioning older adults. The elderly showed the typical age decrement on measures of processing speed, working memory, and inhibition; however WMH severity was significantly related only to processing speed. The strength of this relationship was, however, influenced by the educational level of the participants, such that processing speed was more associated with WMH severity in less-educated than in well-educated participants. This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies.

ACKNOWLEDGMENTS

This work was supported by grants from the National Institute on Aging (AG14051; AG05133) and the National Institute of Mental Health (MH19986; MH60473).

Notes

¹Natural log transformation prior to statistical comparison.

²Square root transformation prior to statistical comparison.