Electroanalytical Determination of Tinidazole by using Surface Modified Carbon Nano Composite based Sensor

ABSTRACT

As an antibiotic, tinidazole (TNZ) is usually consumed to reduce the bacterial infection; thus, qualitative determination of the TNZ is very significant. Thus, in this article, the development of voltammetric sensor based on poly-threonine-modified carbon nanotube-mixed graphene paste electrode (PTRMCNTMGPE) for the detection of TNZ was reported. The PTRMCNTMGPE displayed a boosted electrocatalytic effect regarding the voltammetric signal of the TNZ (pH 7.0) compared to the bare electrode. The morphology of the proposed electrodes was characterised by field emission scanning electron microscopy. The charge transfer resistance of the designed electrode was studied through electrochemical

impedance spectroscopy. The impact of pH and effect of scan rate was studied. The scan rate study reveals the reduction process of the TNZ was controlled by diffusion. The designed electrode yielded low detection limit (0.2 µM) for TNZ. The proposed electrode exhibited a good reproducibility, repeatability, selectivity and an antifouling feature. The practicability of the developed sensor was explored by detecting the TNZ in tablet and blood serum samples.

KEYWORDS:

• Carbon nanocomposite
• voltammetric study
• tinidazole
• poly-threonine-modified electrode
• electropolymerisation

Acknowledgments

We gratefully acknowledge the financial support from the SC/ST Fellowship No. MU/SCT RF/CR17/2017-18 Mangalore University.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

M. M. Charithra

M.M. Charithra presently pursuing a Ph.D. under the guidance of Dr. J.G. Manjunatha at the Department of Chemistry, FMKMC College, A Constituent College of Mangalore University, Madikeri, India. She received her Master's degree in Industrial Chemistry from Mangalore University in 2017. Her main research interests focussed on the fabrication of electrochemical sensors for the analysis of drugs and hormones.

Jamballi G Manjunatha

Jamballi G Manjunatha working as a Assistant Professor in Chemistry at FMKMC College, A Constituent College of Mangalore University, Madikeri, India. He received his Ph.D. degree in Chemistry from Kuvempu University and  Postdoc from the University of Kebangsaan Malaysia. He has received various awards and published more than 121 research articles in reputed International Journals. His research interests focus on the fabrication of electrochemical sensors to detect biologically active molecules and the fabrication of binderless supercapacitors.

N. S. Prinith

N.S. Prinith presently pursuing a Ph.D. under the guidance of Dr. J.G. Manjunatha, Department of Chemistry, FMKMC College, A constituent college of Mangalore University, Madikeri, Karnataka, India. She received her Master's degree in Industrial Chemistry from Mangalore University in 2013. Her present research work interest is based on the development of electrochemical sensors for the voltammetric determination of electroactive molecules.

P. A. Pushpanjali

Pemmatte A Pushpanjali is currently a Ph.D. student working under the guidance of Dr. J.G. Manjunatha at the Department of Chemistry, FMKMC College, A Constituent College of Mangalore University, Madikeri, India. She received her Master's degree in Industrial Chemistry from Mangalore University in 2017. Her main research interests focussed on the fabrication of electrochemical sensors for the analysis of bioactive molecules.

T. Girish

T. Girish is currently a Ph.D. student working under the guidance of Dr. J.G. Manjunatha at the Department of Chemistry, FMKMC College, A Constituent College Mangalore University, Madikeri, India. He received his Master's degree in Chemistry from Davanagere University in 2014. His main research interests focussed on the fabrication of electrochemical sensors for the analysis of electrochemically active molecules.

N. Hareesha

N. Hareesha is currently a Ph.D. student under the guidance of Assistant professor Dr. J.G. Manjunatha at the Department of Chemistry, FMKMC College, A Constituent College of Mangalore University, Madikeri, India. He received his Master's degree in Chemistry from Davanagere University in 2017. His research interests are centered on the development of electrochemical sensors for the electrocatalytic investigation of biologically active molecules.