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Modern Rheumatology Volume 30, 2020 - Issue 1
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Original Articles: Connective Tissue Diseases and Related Disorders

Neutrophil lymphocyte ratio in patients with ankylosing spondylitis: A systematic review and meta-analysis

Shanshan XuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Yubo MaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Meng WuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Xu ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Jiajia YangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Jixiang DengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Shiyang GuanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Xing GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; View further author information
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Shengqian XuDepartment of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; ORCID Iconhttp://orcid.org/0000-0002-9559-1143View further author information
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Zongwen ShuaiDepartment of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; View further author information
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Shihe GuanDepartment of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaView further author information
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Liwen ChenDepartment of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaView further author information
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Faming PanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; ;The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; Correspondence[email protected]
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Pages 141-148 | Received 16 Nov 2018, Accepted 23 Dec 2018, Published online: 23 Apr 2019
 
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Abstract

Objective: The aim of this meta-analysis was to investigate the association of neutrophil lymphocyte ratio (NLR) with AS (ankylosing spondylitis) patients.

Methods: PubMed, Web of Science, Cochrane Library, Elsevier Science Direct and Google Scholar databases (up to 30 September 2018) were searched to collect all pertinent articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random effects model.

Results: Totally 10 studies contained 765 AS patients and 701 healthy controls were included in our meta-analysis. The results indicated that there were significant statistical differences between AS patients and healthy controls in NLR (SMD = 0.418, 95%CI = 0.239–0.598, p < .001). Meanwhile, the results of subgroup analysis showed, in the subgroup of C-reactive protein (CRP) ≥10 and the two subgroups of BASDAI (the Bath AS Disease Activity Index), NLR levels in AS were significantly higher than in control (all p < .001). The results of subgroup analysis and meta-regression suggested that BASDAI and CRP were likely associated with NLR in AS patients.

Conclusion: The current meta-analysis provides evidence that NLR is a reasonable measure to detect systemic inflammation in AS patients. Besides, NLR may be able to indicate disease activity in patients with AS.

Additional information

Funding

The study was sponsored by the National Natural Science Foundation of China (81273169, 81573218, 81773514 and 2017zhyx03).

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