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Abstract
Aims: The detection of false negative results of urine morphine test caused by adulterants was the main goal of this study.
Design/setting: Screening test for urine morphine check was done by two methods of immunochromatography rapid tests and the positive results confirmation was done by thin layer chromatography TLC.
Participants: Urine samples that were referred to the Military Laboratory Science Research Center were used in this study.
Intervention: Sodium chloride, vinegar, lemon juice, nitrites, hydrogen peroxide, bleach, and pH and gravity effects were consider as common adulterants in the urine morphine check.
Measurements: Urine was checked for the presence and absence of the above‐mentioned adulterants in urine samples.
Finding: The study data showed that test performance using the two methods of analysis, using a presence and absence threshold amount of morphine (300 ng/ml), showed a 100% sensitivity for revealing false negative results due to interference with adulterants.
Conclusion: Urine morphine test in double format, with and without threshold amount of morphine, can reveal adulterant interference and prevent false negative reporting. This strategy will be effective in detecting false negatives in urine samples contaminated with adulterants.