AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: recommendations in the use of platelet-rich plasma (PRP), autologous stem cell-based therapy (ASC-BT) in androgenetic alopecia and wound healing

ABSTRACT

Introduction

Many investigations showed that platelet-rich plasma (PRP), human follicles stem cells (HFSCs), and adipose-derived stem cells (ASCs), considered autologous stem cell-based therapy (ASC-BT), are effective for hair regrowth (HR) in patients affected by androgenetic alopecia and for wound healing (WH). The aim of this article is to analyze the in vitro and in vivo impact of different PRP, HFSCs, and ASCs preparation methods on HR and in WH.

Areas Covered

The analyzed data intended to clarify the molecular mechanism in which PRP, HFSCs, and ASCs are involved, the clinical use and related indications, fully respecting the European rules. Comparative studies between different systems of PRP, HFSCs, and ASCs preparation revealed differences in terms of HR and WH.

Expert Opinion

Despite a lack of standardized protocols, there is convincing evidence with objective measurement modalities that display positive outcomes of ASC-BT in HR and WH.

KEYWORDS:

• Plastic surgery
• regenerative plastic surgery
• platelet-rich plasma
• PRP in androgenetic alopecia
• PRP in hair loss
• human follicle stem cells
• HFSC
• adipose-derived stem cells
• ASCS
• hair regrowth
• wound healing

Article highlights

• Platelet-rich plasma (PRP), human follicles stem cells (HFSCs), and adipose-derived stem cells (ASCs) in hair regrowth.

• Autologous stem cell-based therapy (ASC-BT) in hair regrowth.

• PRP, HFSCs, and ASCs, in wound healing (WH).

• ASC-BT in WH.

• Recommendations in androgenetic alopecia and WH.

• In vitro and in vivo impact of different PRP, HFSCs, and ASCs preparation methods on HR and in WH.

This box summarizes key points contained in the article.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Author contributions

P.G. was the leader and principal investigator of this paper, performing the methodology, formal analysis, conceptualization, data curation, investigation, validation, writing—original draft preparation, writing—review and editing, acquisition funding and resources and project administration, analysis of European and Italian rules; R.A., J.P.C, K.A., T.V.H, J.F., A.T., L.G., A.V., P.T., J.M., and G.M. contributed resources and were involved in data curation and visualization; S.M. contributed resources, data curation, validation, review, and editing. All authors have agreed to the final version to be published and agree to be accountable for all aspects of the work.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial relationships or otherwise to disclose.

Additional information

Funding

This research received no external funding.