Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers

ABSTRACT

Objective

To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers.

Methods

Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg’s funnel plots and Egger’s test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis.

Results

Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, P<0.05), tumor size (OR=2.29, 95% CI: 1.38-3.79, P<0.05), metastasis (OR=2.97, 95% CI: 2.06-4.28, p<0.05) and overall survival of cancer (OR=3.30, 95% CI: 2.26-4.84, p<0.05), but not associated with age and gender of patients with tumor. No publication bias was found.

Conclusions

High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers. 

KEYWORDS:

• CircPVT1
• cancers
• clinical features
• prognosis
• meta-analysis

Acknowledgments

The authors would like to thank Dr. Ayub Abdulle nur and Dr. Zhen Zhou for English language support in this manuscript.

Declaration of interest

The author(s) have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Authors’ contributions

JZ and YL drafted the manuscript. JZ, HZ, DZ, ZZ and TL revised the manuscript. TL and WW contributed to the revision of manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable.

Availability of data and material

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This work was supported by the Fundamental Research Funds for the Central Universities of Central South University [Grant No. 2018zzts930].