ABSTRACT
Background
To observe the level of serum Sema7A in acute aortic dissection (AAD) and its diagnostic value for AAD.
Research design and methods
Patients with sudden chest pain including AAD, acute myocardial infarction (AMI) or pulmonary embolism (PE) were enrolled. Patients without chest pain or cardiovascular diseases were included as the controls. Serum Sema7A and plasma D-dimer were detected and compared in each group.
Results
85 AAD patients, 55 AMI patients, 15 PE patients, and 30 controls were enrolled. The concentration of Serum Sema7A in the AAD group was significantly higher than that in the control, AMI and PE group. Serum Sema7A was positively correlated with D-dimer. In AAD patients who underwent invasive intervention therapy, serum Sema7A levels were significantly decreased after the intervention. Serum Sema7A was an independent risk factor for the presence of AAD. The areas under the ROC curve of Sema7A and D-dimer for differential diagnosis of AAD from other chest pain disorders were 0.842 (0.776, 0.909) and 0.788 (0.714, 0.862), respectively.
Conclusions
Sema7A is highly expressed in patients with AAD. Sema7A might be a valuable biomarker for the early diagnosis of AAD and has the potential to differentiate AAD from AMI and PE.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. The authors declare no competing interests.
Authors’ contributions
X Lyu: Conceptualization, Methodology, Visualization, Funding acquisition, Writing – Original Draft; X Liu: Formal analysis, Data Curation, Writing – Original Draft; X Zhang: Writing – Review & Editing, Funding acquisition, Supervision; H Gong: Investigation, Data Curation; Y Liu: Resources, Data Curation; Z Zhou: Resources, Data Curation; M Hu: Investigation.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Availability of data
All data in this study may be available from the corresponding author upon reasonable request.