Advanced search
Publication Cover
Expert Review of Neurotherapeutics Volume 16, 2016 - Issue 7
Submit an article Journal homepage
509
Views
5
CrossRef citations to date
0
Altmetric
Review

Anti N-methyl-D-aspartate receptor encephalitis: a game-changer?

Corinne E. FischerKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada;Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada;Faculty of Medicine, Department of Psychiatry, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]
,
Angela C. GolasDepartment of Psychiatry, University of Toronto, Geriatric Psychiatry Subspecialty, Toronto, ON, Canada
,
Tom A. SchweizerKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada;Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada;Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada;Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Division of Neurosurgery, St. Michael’s Hospital, Toronto, ON, Canada
,
David G. MunozKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada;Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;Division of Pathology, Department of Laboratory Medicine and Pathobiology, St. Michael’s Hospital, Toronto, ON, Canada
,
Zahinoor IsmailHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
,
Winnie QianKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada;Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
,
David F. Tang-WaiDepartment of Medicine (Neurology and Geriatric Medicine), University of Toronto, Toronto, ON, Canada;UHN Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada
,
Dalia L. RotsteinDepartment of Medicine (Neurology), University of Toronto, St. Michael’s Hospital, Toronto, ON, Canada
&
Gregory S. DayKnight Alzheimer Disease Research Center, Department of Neurology, Washington University in St. Louis, St. Louis, MO, Canada
 show all
Pages 849-859 | Received 08 Mar 2016, Accepted 26 Apr 2016, Published online: 17 May 2016
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an inflammatory disorder of the brain that has garnered significant interest within the medical and lay communities. There is a need for formal guidelines to assist physicians in identifying patients who should undergo testing for NMDAR encephalitis, recognizing the high potential for this potentially treatable disease to mimic more common disorders, and consequently remain undiagnosed.

Areas covered: This review highlights the impact of the discovery of NMDAR encephalitis on the fields of neurology and psychiatry, and discusses the steps that are necessary to improve recognition and treatment of NMDAR encephalitis.

Expert commentary: While much progress has been made in our understanding of NMDAR encephalitis, much work remains to be done to delineate the underlying disease mechanisms and their relevance to brain function.

Declaration of interests

G Day receives research support via the American Academy of Neurology/American Brain Foundation Clinical Research Training Fellowship. He is involved in research supported by an in-kind gift of radiopharmaceuticals from Avid Radiopharmaceuticals, and is currently participating in clinical trials of anti-dementia drugs sponsored by the A4 (The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease) trial. He holds stocks (>$10,000) in ANI Pharmaceuticals (a generic pharmaceutical company). He is also the Clinical Director of the Anti-NMDA Receptor Encephalitis Foundation, Inc (Canada). The Foundation is supported by private donation; G Day is not directly compensated for his work with the Foundation. D Rotstein received research support from the MS Society of Canada and Biogen Idec and has served as a consultant for Novartis, EMD Serono, and Sanofi. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 651.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.