ABSTRACT
Background
Calcitonin gene-related peptide (CGRP) antagonists are recently approved for the treatment of migraine.
Aim
The main aim of the current study was to find out the association of CGRP antagonists with RP using data mining algorithms integrated with network pharmacological approaches.
Research design and methods
The individual case safety reports were extracted using OpenVigil2.1-MedDRA-V17 (2004Q1-2022Q3), the United States Adverse Event Reporting System (US FAERS). The data mining algorithms i.e. reporting odds ratio (ROR) with 95% confidence and proportionality reporting ratio (PRR) with associated chi-square value were calculated along with a minimum of three ICSRs to identify the signal. Further, the network was constructed using Cytoscape 3.7.2. Finally, molecular docking was performed using Glide, Schrodinger Inc.
Results
The PRR ≥2 with a linked chi-square value ≥4, add up of co-occurrence ≥3, and a lower limit of 95% confidence interval of ROR exceeding 2 indicates a positive signal of RP. Further, the network pharmacological and molecular docking results have shown the involvement of insulin-like growth factor 1-receptor (IGF1R) pathways.
Conclusion
The RP is recognized as a novel signal with all CGRP antagonists.
Declaration of interests
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
One reviewer is currently employed at Lundbeck. The remaining reviewers have no other relevant financial relationships or otherwise to disclose.
Author contribution statement
RS conducted the study and prepared the first draft; VL performed the docking studies; RS revised the manuscript; DP and AK have designed and revised the manuscript.
Acknowledgments
The author would like to acknowledge Professor (Dr) R.K. Goyal Vice-chancellor of Delhi Pharmaceutical Sciences and Research University, New Delhi-110017, for his continuous support, motivation, and providing necessary facilities to carry out this work.