https://orcid.org/0000-0002-6739-0387
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ABSTRACT
Background
Alopecia areata (AA) is a non-scarring disorder characterized by hair loss that greatly affects patients’ quality of life and has a chronic, recurring course. This disease is marked by an inflammatory process, mainly on an autoimmune basis primarily regulated by Janus kinase (JAK).
Research design and methods
We conducted a retrospective study evaluating the safety of JAKi in a real-world setting in 91 AA patients, with a specific focus on the assessment of infectious events.
Results
Overall, 34 infectious events were observed in 28 patients (30.8%), among them 17 patients (60.7%) suspended treatment with JAKi until the infection was clinically resolved. Only in one case the infectious event led to a permanent discontinuation of the treatment. The data we observed in the study are consistent with results reported in clinical trials.
Conclusion
It can be stated that, during treatment with JAKi in AA patients, infectious events may occur, but in most cases these events are easily manageable and do not result in permanent discontinuation of the drug.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
Peer reviewers in this manuscript have no relevant financial or other relationships to disclose.
Author Contribution
Conceptualization, G.C. and L.M.P.; writing – original draft preparation, G.C., L.M.P., and E.T.; data acquisition, G.C., L.M.P., F.B, N.B, E.C, L.C., L.D, P.G., E.M., E.T., E.T.; writing – review and editing, G.C., A.C.; supervision, C.D.S, L.B. and K.P. All authors have read and agreed to the published version of the manuscript.