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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 18, 2003 - Issue 6
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Research Article

Curcumin as a DNA Topoisomerase II Poison

Carmen Martín-Cordero Laboratorio de Farmacognosia, Facultad de Farmacia, C/P. García González No. 2, 41012, Sevilla, Spain
,
Miguel López-Lázaro Laboratorio de Farmacognosia, Facultad de Farmacia, C/P. García González No. 2, 41012, Sevilla, Spain
,
Marina Gálvez Laboratorio de Farmacognosia, Facultad de Farmacia, C/P. García González No. 2, 41012, Sevilla, Spain
&
Maria Jesús Ayuso Laboratorio de Farmacognosia, Facultad de Farmacia, C/P. García González No. 2, 41012, Sevilla, SpainCorrespondence[email protected]
Pages 505-509 | Received 02 Jun 2003, Accepted 16 Jul 2003, Published online: 03 Oct 2008
 
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Abstract

Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains poorly understood. Curcumin has been assessed on the human cancer cell lines, TK-10, MCF-7 and UACC-62, and their IC50 values were 12.16, 3.63, 4.28 μM respectively. The possibility of this compound being a topoisomerase II poison has also been studied and it was found that 50 μM of curcumin is active in a similar fashion to the antineoplastic agent etoposide. These results point to DNA damage induced by topoisomerase II poisoning as a possible mechanism by which curcumin initiates apoptosis, and increase the evidence suggesting its possible use in cancer therapy.

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