Syntheses and anti-inflammatory activity of Diphenylamine-2,2′-dicarboxylic acid and its metal complexes

Abstract

Diphenylamine-2,2′-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for its anti-inflammatory activity and found to be equipotent to naproxen and ibuprofen, though at higher doses.

Keywords: :

• Metal complex
• NSAID'S
• prostaglandins
• anti-inflammatory agent