The publishers would like to apologise for an error that occurred in an article entitled:
Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors.
The article was published in Journal of Enzyme Inhibition and Medicinal Chemistry, October 2008; 23(5): 629–640.
The Scheme in this paper should have appeared as follows:
Scheme 1 Synthesis of 5-benzyloxy-4-oxo-4H-pyran-2-carboxamide and [6-aminocarbonyl-3-benzyloxy-4-oxo-4H-pyran-2-yl]methyl diethyl phosphate derivatives 18–37. Reagents and conditions: (i) DHP, PTSA.H2O, CH2Cl2, rt, 2; (ii) HCHO, NaOH/H2O, rt, 3; (CH3)2CHCHO, NaOH/H2O, rt, 4; HCHO, NaOH/H2O, MeOH, rt, 5; (iii) BnBr, NaOH/H2O, MeOH, Δ, 6–9; (iv) ClP(O)(OC2H5)2, pyridine, DMAP, CH2Cl2, rt, 10; (v) Zn/HCl, H2O, 70°C, 11, 12; (vi) HCl 1N, Δ, 13; (vii) CrO3, H2SO4, acetone, 0°C or − 20°C, 14–17; (viii) Method A: TBTU, Et3N, toluene/acetonitrile, rt, 18–20; Method B: DEPBT, DIEA, THF, Δ, 21, 22; Method C: CMPI, Et3N, CH2Cl2, Δ, 23–37.
![Scheme 1 Synthesis of 5-benzyloxy-4-oxo-4H-pyran-2-carboxamide and [6-aminocarbonyl-3-benzyloxy-4-oxo-4H-pyran-2-yl]methyl diethyl phosphate derivatives 18–37. Reagents and conditions: (i) DHP, PTSA.H2O, CH2Cl2, rt, 2; (ii) HCHO, NaOH/H2O, rt, 3; (CH3)2CHCHO, NaOH/H2O, rt, 4; HCHO, NaOH/H2O, MeOH, rt, 5; (iii) BnBr, NaOH/H2O, MeOH, Δ, 6–9; (iv) ClP(O)(OC2H5)2, pyridine, DMAP, CH2Cl2, rt, 10; (v) Zn/HCl, H2O, 70°C, 11, 12; (vi) HCl 1N, Δ, 13; (vii) CrO3, H2SO4, acetone, 0°C or − 20°C, 14–17; (viii) Method A: TBTU, Et3N, toluene/acetonitrile, rt, 18–20; Method B: DEPBT, DIEA, THF, Δ, 21, 22; Method C: CMPI, Et3N, CH2Cl2, Δ, 23–37.](/cms/asset/e4d42134-392a-412c-8ef7-978a39e3f4e6/ienz_a_351233_f0001_b.gif)