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Expert Review of Vaccines Volume 20, 2021 - Issue 5
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Original Research

Retrospective analysis of bacterial culture-confirmed pertussis cases in Beijing Children’s hospital from 2014 to 2019 reveals prevention and control of the grim situation in mainland China

Dandan Liua MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Qianqian Dua MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Lin Yuana MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Qing Wanga MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Wei Shia MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Qinghong Menga MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Dan Yua MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaView further author information
&
Kaihu Yaoa MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;b Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1548-8670View further author information
ORCID Icon show all
Pages 577-583 | Received 02 Dec 2020, Accepted 03 Mar 2021, Published online: 19 Mar 2021
 
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ABSTRACT

Background

Our study aims to explore the epidemiological features of children with bacterial culture-confirmed pertussis visiting Beijing Children’s Hospital, China.

Methods

From 2014 through 2019, patients with suspected pertussis coming from mainland China provided nasopharyngeal swabs and bacterial culture that was subsequently cultivated.

Results

During the study period, 6956 children with suspected pertussis from 30 different administrative provinces of mainland China were investigated, of which 1494 cases (21.5%) had positive B. pertussis culture. The number of pertussis cases increased year-on-year, from 122 in 2014 to 279 in 2019. Of the confirmed cases, 38.2% and 26.8% were identified in the summer and autumn, respectively. The age distribution of children with pertussis showed that 77.2% were <12 months old, including 56.0% <6 months old. Only thirteen B. parapertussis isolates and one B. bronchiseptica isolates were collected in the present samples.

Conclusions

The present culture-confirmed cases reveal the severe epidemic situation of pertussis spreading over the whole country and mainly affecting the infants. It is necessary to set up hospital-based surveillance with reliable laboratory methods to promote clinical awareness and to monitor the disease.

Acknowledgments

We thank all patients and their parents who made this work possible, and all study clinical staff at Beijing Children’s Hospital, Beijing, China. We are also grateful to China CDC for providing access to the data used in this study.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Author contributions statement

Kaihu Yao conceived and designed the study. Lin Yuan, Qing Wang, Wei Shi, Qinghong Meng, DanYu, Dandan Liu, Qianqian Du, Wei Shi did the clinical data collection and performed the experiments. Dandan Liu, Kaihu Yao analyzed the data. Dandan Liu wrote the first draft of the manuscript and Kaihu Yao revised the manuscript. All authors read and approved the final manuscript.

Additional information

Funding

This work was supported by National Natural Science Foundation of China [grant number 81973100], and Natural Science Foundation of Beijing - Haidian Original Innovation Fund Joint Project [grant number 19L2041].

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