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The Journal of Maternal-Fetal & Neonatal Medicine Volume 30, 2017 - Issue 5
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Short Report

Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs

Teresa Mary MacDonaldTranslational Obstetrics Group, Mercy Hospital for Women, Melbourne, Heidelberg, Australia, ;Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and ;Perinatal Department, Mercy Hospital for Women, Melbourne, Heidelberg, AustraliaCorrespondence[email protected]
,
Tu’uhevaha Joy Kaitu’u-LinoTranslational Obstetrics Group, Mercy Hospital for Women, Melbourne, Heidelberg, Australia, ;Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and
,
Susan Philippa WalkerDepartment of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and ;Perinatal Department, Mercy Hospital for Women, Melbourne, Heidelberg, Australia
,
Kirsten Margaret DanePerinatal Department, Mercy Hospital for Women, Melbourne, Heidelberg, Australia
,
Elizabeth Beatrice LockieDepartment of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and ;Perinatal Department, Mercy Hospital for Women, Melbourne, Heidelberg, Australia
,
Stephen TongTranslational Obstetrics Group, Mercy Hospital for Women, Melbourne, Heidelberg, Australia, ;Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and
,
Clare Louise WhiteheadTranslational Obstetrics Group, Mercy Hospital for Women, Melbourne, Heidelberg, Australia,
&
Lisa HuiTranslational Obstetrics Group, Mercy Hospital for Women, Melbourne, Heidelberg, Australia, ;Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, and ;Perinatal Department, Mercy Hospital for Women, Melbourne, Heidelberg, Australia
 show all
Pages 501-503 | Received 01 Dec 2015, Accepted 10 Apr 2016, Published online: 05 May 2016
 
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Abstract

Background: It is not known whether fasting affects levels of circulating placenta-specific transcripts.

Objective: To assess whether a glucose load affects circulating placenta-specific transcripts.

Method: RNA was extracted from paired blood samples (fasting and 1-h post 75 g oral glucose) from 22 women. Placenta-specific genes were measured by RT-qPCR.

Results: There was no change in ADM, CSH1, PAPPA2, PSG1 or TAC3 expression between fasting and post-glucose states. However, HTRA1 decreased after glucose load.

Conclusion: Maternal fasting state does not influence expression of the majority of placenta-specific genes but may need to be accounted for when validating biomarkers of placental disease.

Acknowledgements

We wish to thank the pathology and health information services staff at the Mercy Hospital for Women for their assistance in conducting this research.

Declaration of interest

The authors report no conflict of interest. This study was supported by NHMRC Grant 1065854 and RANZCOG Taylor Hammond Scholarship with thanks.

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