Analysis of amino acids and acyl carnitine profiles in low birth weight, preterm, and small for gestational age neonates

Abstract

Objective: To analyze the amino acids (AA) and acyl carnitine (AC) profiles in dry blood spot (DBS) specimens of low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA), and to compare the concentration difference of AA and AC with those without above.

Methods: This is a retrospectively study. Eight thousand nine hundred and seventy-nine uncomplicated pregnant newborns were enrolled into the study. DBS were collected on the third day of life, and concentrations of 11 types of AA, free carnitine and 30 types of AC were detected by using high-performance liquid chromatography tandem mass spectrometry (HPLC–MS). Shapiro–Wilk test and Kruskal–Wallis rank test were applied in statistical analysis.

Results: Concentrations of most AA and AC in infants born in SGA were significantly higher than those in non-SGA group, while lower in LBW and PTB groups than those in non-LBW and non-PTB groups (p < 0.05).

Conclusions: The difference of concentration of AA and AC in the subgroups suggested there may be a dysutilization of AA and AC in SGA, but an inborn insufficient of AA and AC in LBW and PTB neonates.

Keywords:

• “Amino acids/analysis” [Mesh]
• “carnitine/analysis” [Mesh]
• low birth weight
• preterm birth
• small for gestational age

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.