First-trimester reference centiles of fetal biometry in Indian population

Abstract

Aim and objective: To create crown-rump length (CRL)-based biometric chart for fetus in the first trimester among the Indian population.

Material and methods: Cross-sectional data were obtained from 400 singleton pregnancies between 11 and 14 weeks gestation with a normal outcome. Linear regression models were constructed; the mean and SD were derived as a function of CRL.

Results: There was a positive correlation of CRL with nuchal translucency (NT) (y = 0.0102x + 0.6307 R²=0.1177), biparietal diameter (BPD) (BPD = 0.032*CRL +0.185 R²=0.765), occipito-frontal diameter (OFD), lateral ventricular diameter (LV), abdominal circumference (AC) (AC = 0.944*CRL +9.684 R²=0.668), femur length (FL) (FL = 0.222*CRL −4.734 R²=0.661), fetal weight (FW) (FW = 1.328*CRL −10.41 R²=0.662). The regression models and centile charts of NT, BPD, OFD, LV, AC, and FW were constructed. Taking FW as the independent variable, a linear equation of BPD, AC, and FL to calculate weight was constructed.

Conclusions: The first-trimester centile charts of fetal parameters can be used as a reference for Indian population in the determination of gestational age or other adverse outcomes.

Keywords:

• Ultrasound
• first trimester
• nuchal translucency
• biparietal diameter

Acknowledgements

The study was funded by Indian Council of Medical Research, an Indian-government aided funding agency.

Disclosure statement

There is no conflict of interest among authors. There was no relationship of any of the authors with companies that may have a financial interest.

Additional information

Funding

This study was funded by Indian Council of Medical Research, an Indian-government aided the funding agency.