Comparison of two-risk assessment algorithms for preeclampsia in first trimester with consecutive intake of low-dose aspirin in the high-risk group – an observational study

Abstract

We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor^®Software by PerkinElmer, PerkinElmer, Waltham, MA; PERK-group: n = 214 and Viewpoint^® by GE Healthcare, Dornstadt, Germany; VIEW-group: n = 209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic acid (LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% versus 26.3%; p = 0.000). According the clinical use of screening test criteria, LDA was prescribed in 63 (29.4%) women in the PE-group and 55 (26.3%) in the VP-group (p = 0.516). There were no differences in onset of preeclampsia [4 (1.9%) versus 6 (2.9%); p = 0.540]. No early or severe preeclampsia occurred in the whole population.

Keywords:

• Preeclampsia
• first-trimester screening
• aspirin
• low-dose acetylsalicylic acid

Acknowledgements

The authors would like to acknowledge the staff of the Department of Obstetrics at the Medical University of Graz, Austria.

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

There was no funding source for this study.