Serum endothelin-1 and placental alkaline phosphatase levels in placenta percreta and normal pregnancies

Abstract

Purpose: To evaluate the circulatory levels of endothelin 1 (ET-1) and the placental alkaline phosphatase (ALP) in pregnant women with placenta percreta (PP) and a control group.

Methods: This study was carried out in the Obstetrics and Gynecology and in the Biochemistry Departments of Harran University Medical School. Forty-four women who underwent cesarean section (CS) due to PP and 44 women who underwent CS for other obstetric reasons were included in this study. The PP diagnosis was made by a pathologic examination that showed an extreme trophoblastic invasion involving the uterine serosa.The levels of circulating ET-1 and placental ALP were measured by an enzyme-linked immunosorbent assay (ELISA).

Results: Women with PP more frequently received antenatal steroids and blood transfusions and they delivered at an earlier gestational age compared to controls. In women with PP, preoperative circulating ET-1 and placental ALP levels were lower than in the controls (p < .05 for both).

Conclusions: The findings suggest that a decrease in ET-1 and placental ALP levels might play a role in the pathogenesis of PP.

Keywords:

• Endothelin 1
• placental ALP
• placenta percreta
• invasion

Acknowledgements

We would like to thank all the subjects who participated in this study. Also, we thank Professor Tevfik Sabuncu for supporting statistical analyses, and our biochemistry team.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (28.08.2015- Number: 15120).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Disclosure statement

All the authors declare that they have no conflict of interest.