Effect of two high dose vitamin D by parenteral route in treating vitamin D deficiency a prospective interventional study

Abstract

Background: Vitamin D deficiency is recognized as a global public health problem. Despite ample sunshine, vitamin D deficiency is very common in the Middle East (15°–36°N) and African (35°S–37°N) countries; and in South Asian countries.

Aim: To find a simple, affordable and practical plan to treat vitamin-d deficiency.

Type of study: This was a prospective interventional study.

Outcome variable: The primary outcome was typed as vitamin-D level more than 50 nanograms/ml as ‘yes’ and poor response or ‘no’ when it was less than 50 ng/ml.

Participants: 80 Women participated in study.

Laboratory tests: Vitamin D [25-OHD]-estimations were performed with LCMSMS-liquid chromatography tandem mass spectrometry.

Corrective vitamin-D doses: All participants received TWO doses of Vitamin-D injections one ml at a time [600K IU/ml or 600,000 IU/ml]. All participants received their first dose; after collecting blood samples for Vitamin-D estimations. Second dose was given about a month after the first one [range 30–37 days]. These doses were given to correct the deficiency.

Results: Even with this high dose treatment 60% woman had unsatisfactory Vitamin-D levels.

Keywords:

• Genetic factors-VDBP
• high hydroxylase enzyme activity
• mega dose parenteral therapy
• treatment of vitamin D deficiency
• variable responses

Disclosure statement

No potential conflict of interest was reported by the authors.