Declaration of interest
D Alexopoulos has received advisory board fees from Astrazeneca, Boehringer Ingelhein, Bayer and The Medicines Company and lecturing honoraria from Astrazeneca. J Lekakis has received advisory board fees and lecturing honoraria from Astrazeneca, Actelion and MSD. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.