A new BIS-Andrographolide Ether from Andrographis paniculata Nees and evaluation of anti-HIV activity

Abstract

Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (±)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.

Keywords:

• Andrographis paniculata
• Acanthaceae
• Bis-andrographolide ether
• Anti-HIV
• Cytotoxic activity

Acknowledgments

We are thankful to by Dr. K. Madhava Chetty, Department of Botany, Sri Venkateswara University, Tirupati, India for identifying the plant and Dr. J.S. Yadav, Director IICT for encouragement. VLNR, SMR, VR, PK and TVG are thankful to the Ministry of Health, New Delhi and CSIR New Delhi for providing fellowships, respectively.

Notes

IICT Communication No.: 021012

Additional information

Notes on contributors

Y. Venkateswarlu

IICT Communication No.: 021012