Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation

Abstract

Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC₅₀ values of 2.9 and 1.7 μM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.

Keywords:

• Diarylheptanoids
• Low-density lipoprotein oxidation
• Alnus japonica

Acknowledgements

This research was financially supported by a grant (code: PF0320506-0) from the Plant Diversity Research Center of 21st Century Frontier Research Program, a grant of Biogreen 21 Program of the Rural Development Administration, and the KRIBB Research Initiative Program.