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Natural Product Research
Formerly Natural Product Letters
Volume 21, 2007 - Issue 14
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Original Articles

Liposomes from a new chiral cationic lipid based on iridoidic template

Armandodoriano Bianco Dipartimento di Chimica, Università “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, ItalyCorrespondence[email protected]
,
Raffaella Napolitano Dipartimento di Chimica, Università “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, Italy
,
Francesco Bonadies Dipartimento di Chimica, Università “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, Italy
,
Diana Celona Dipartimento di Chimica, Università “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, Italy
,
Giancarlo Ortaggi Dipartimento di Chimica, Università “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, Italy
&
Cesare Cametti Dipartimento di Fisica, Università “La Sapienza” and INFM-CRS-SOFT, Unità, di Roma
Pages 1221-1227 | Received 14 Aug 2004, Accepted 24 Mar 2005, Published online: 12 Dec 2007
 
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Abstract

A new cationic polyhydroxylated lipid, characterized by a chiral template, was synthesized. It comes from an iridoid glucoside, as polyhydroxylated moiety. This lipid affords liposomes using cholesterol-like co-lipid. The liposomes had a spheroidal shape with a small size distribution.

Acknowledgement

The financial support from FIRB-MIUR is acknowledged.

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