Ellagic acid glycosides from Turpinia ternata

Abstract

Bioassay-guided fractionation of the methanolic extract of Turpinia ternata stems, has led to the isolation of the new ellagic acid derivative 3,4′-di-O-methylellagic acid-4-O-α-L-arabinofuranoside (1), and the known compounds ellagic acid (2), 3-O-methyl ellagic acid (3), 3-O-methylellagic acid-3′-O-α-L-rhamnopyranoside (4), and 3,3′-di-O-methylellagic acid-4′-O-α-D-glucopyranoside (5). Their structures were elucidated by extensive spectroscopic methods. Compounds 1, 3, and 4 showed moderate antioxidant activity against DPPH free radical, whereas compound 1 was found to be moderately cytotoxic against Artemia salina larvae.

Keywords:

• Turpinia ternata
• Staphyleaceae
• Ellagic acid derivatives
• Antioxidant activity

Acknowledgement

Foundation for Science and Technology, Portugal, for a post-doc grant (S. Matthew, SFRH/BPD/8570/2002).