New phenolic glycosides from the stems and leaves of Casearia multinervosa

Abstract

Four phenolic glycosides (1−4), including two new ones (3 and 4), have been isolated from the stems of Casearia multinervosa and identified as arbutin (1), 4-O-E-caffeoylarbutin (2), 4-O-E-coumaroylarbutin (3) and 4-O-E-feruloylarbutin (4), respectively. In addition, the two known phenolic glycosides (1 and 2) were also isolated from the leaves. Structures were elucidated on the basis of spectroscopic evidence. Compounds 1−4 were tested for cytotoxicity against the P388 mouse lympholytic cell line by an ATP Lite-M assay method and showed mild to moderate activity.

Keywords:

• Casearia multinervosa
• Flacourtiaceae
• Salicaceae
• Phenolic glycosides
• Cytotoxicity

Acknowledgement

The authors wish to extend their sincere thanks to the Commonwealth Government for the award of a (IPRS) scholarship and to the Southern Cross University for the award of a (UPRS) scholarship to the first author. Thanks are also due to the Chemistry Department of Wollongong University, NSW, Australia for providing the HR-Mass data.

Notes

†In memory of Dr. Andrew Flowers.

Additional information

Notes on contributors

Mosaddik Andrew Flowers†

†In memory of Dr. Andrew Flowers.