New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum

Abstract

Two new lanostanoids, 7-oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.

Keywords:

• Ganoderma lucidum
• Ganodermataceae
• Mushroom
• Lanostanoid
• 3β-Hydroxy-7-oxo-5α-lanosta-8,24(E)-dien-26-oic acid
• 15α-Hydroxy-3-oxo-5α-lanosta-7,9(11),24(E)-trien-26-oic acid
• HMG-CoA reductase
• Acyl CoA acytransferase