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Natural Product Research
Formerly Natural Product Letters
Volume 22, 2008 - Issue 13
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Original Articles

An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation

Khalid Mohammed Khan H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, PakistanCorrespondence[email protected]
,
Sumbul Ahmed H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
,
Zulfiqar Ali Khan H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
,
Mubeen Rani H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
,
Shahnaz Perveen PCSIR Laboratories Complex Karachi, Off University Road, Karachi, Pakistan
&
Wolfgang Voelter Interfakultäres Institut für Biochemie der Universität Tübingen, Tübingen, Germany
Pages 1120-1127 | Received 28 Nov 2005, Accepted 11 Aug 2006, Published online: 14 Oct 2008
 
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Abstract

A microwave-assisted, environmentally friendly, high-yielding, time-saving synthesis of medicinally important 3-substituted isocoumarins was carried out in a single step by direct condensation of homophthalic acid with aryol and acyl chlorides under solvent-free conditions without any solid support. The synthesised isocoumarins were structurally characterised by microanalysis, 1H NMR, EI, IR and UV.

Acknowledgement

The authors are thankful to the Higher Education Commission (HEC) Pakistan for generous financial support under the ‘National Research Program for Universities’.

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