Lower homologues (methyl, ethyl) of diorganotin derivatives of germyl (substituted) propanoic acids: spectroscopic elucidations and biological studies

Abstract

Some novel lower homologues of diorganotin derivatives of germyl substituted propanoic acids with general formula [Ar₃GeCH(R¹)CH(R²)COO]₂ , where Ar = p-CH₃C₆H₄, C₆H₅, R¹ = p-CH₃C₆H₄, p-CH₃OC₆H₄, o-CH₃OC₆H₄, C₆H₅, R² = H, CH₃, R³ = CH₃, C₂H₅ have been prepared by the condensation reaction of dialkyltin oxide and triarylgermyl(substituted) propanoic acid in 1 : 2 M ratio, respectively, and were characterized by IR, multinuclear (¹H, ¹³C, ¹¹⁹Sn) NMR, ^119mSn Mössbauer spectroscopy. The synthesized compounds were also screened for their toxicity and possible antibacterial, antifungal activities and found some encouraging results.

Keywords:

• Dialkyltin
• Germyl
• Spectroscopy
• Antibacterial
• Antifungal

Acknowledgment

Dr Imtiazud-din is thankful to Quaid-i-Azam University, Islamabad for awarding Postdoctoral Research Fellowship and appreciates its financial support.